With a 73-litre fuel tank (66 litres plus a 7-litre reserve) theoretically an E220d will go 1100 miles between refills, and the E400d a potential 884 miles. The reality is the E220d struggles to match its claimed 73mpg, and a figure in the high 50s is more likely in real world driving. The 400d has a claimed 55mpg figure.
The four-cylinder diesel just misses out on a sub 100g/km figure, producing 102g/km of CO2, with the E400d emitting 133g/km.
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Mercedes has never been one to offer overly large alloy wheels as standard, and the new E is no exception. The 220d comes with a 17-inch wheel and 225/55 front and rear tyres, and the six-cylinder diesel with an 18-inch wheel wearing 245/45 rubber, which should prevent any nasty costs come replacement time.
E63 S models, of course, have much higher running costs, with massive tyres and brakes and other consumables. The biggest cost will likely remain fuel though, as the E63 realistically achieves somewhere between 20 and 25mpg at the absolute most.